Homozygous haemoglobin E in association with hereditary ovalocytosis.

Hereditary ovalocytosis in Malays.

Since the first description of hereditary ovalocytosis in Malayan aborigines 1 1965, high frequencies of hereditary ovalocytosis have been reported in South East Asia?,3 Biophysical studies showed a strong correlation between increased membrane rigidity and decreased malarial parasite invasion in hereditary ovalocytosis in the Malayan aborigines." The literature currently available describes he...

The homozygous state for the band 3 protein mutation in Southeast Asian Ovalocytosis may be lethal.

Brief report The association of the glycophorin C exon 3 deletion with ovalocytosis and malaria susceptibility in the Wosera, Papua New Guinea

Erythrocyte polymorphisms, including ovalocytosis, have been associated with protection against malaria. This study in the Wosera, a malaria holoendemic region of Papua New Guinea, examined the genetic basis of ovalocytosis and its influence on susceptibility to malaria infection. Whereas previous studies showed significant associations between Southeast Asian ovalocytosis (caused by a 27– base...

The association of the glycophorin C exon 3 deletion with ovalocytosis and malaria susceptibility in the Wosera, Papua New Guinea.

Erythrocyte polymorphisms, including ovalocytosis, have been associated with protection against malaria. This study in the Wosera, a malaria holoendemic region of Papua New Guinea, examined the genetic basis of ovalocytosis and its influence on susceptibility to malaria infection. Whereas previous studies showed significant associations between Southeast Asian ovalocytosis (caused by a 27- base...

Hereditary ovalocytosis in Melanesians.

A distinctive type of hereditary ovalocytosis has been found in Papua New Guinea and a few areas of Southeast Asia. Its main features include a high incidence among tropical lowland dwellers, autosomal recessive inheritance, specific depression of a number of red cell antigens, a characteristic morphology in blood films, and an effect on the erythrocyte sedimentation rate. Speculation has occur...